These AI-designed proteins work as biosensors, reporting a measurable output when they detect their target ...

AI protein function prediction is reshaping how laboratories approach protein annotation, hypothesis generation, and translational research. As sequencing technologies continue to outpace experimental ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

Using bright X-rays from the Department of Energy's SLAC National Accelerator Laboratory and Lawrence Berkeley National ...

It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing ...

Proteins are most well-known for their intricate structures. The α-helices and β-sheets that form from interactions between sidechains create distinct shapes that, along with the specific amino acid ...

A change in the DNA sequence of a codon may not change the corresponding amino acid residue in the encoded protein because each residue can be encoded by several codons. This is called the Wobble ...

Scientists have uncovered an unexpected way cells can generate cancer-driving proteins—by cutting RNA into shorter, ...