USB devices are block devices like any other. Linux doesn't care if you install or boot from a SATA disk or a USB disk, it makes no differences in that regard. The only niggle is can be BIOS support, ...
Due to the recent unfortunate demise of a couple of my computers I found myself in need of a new laptop on rather short notice. I found an Acer Aspire 5 on sale at about half price here in Switzerland ...
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